Physiological Chemistry
print
Search
Hinweise zur Datenübertragung bei der Google™ Suche
Links and Functions
Breadcrumb Navigation
Content

Publications

2018 - 2012

  • A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast.
    Specht S, Liedgens L, Duarte M, Stiegler A, Wirth U, Eberhardt M, Tomás A, Hell K, Deponte M.
    Redox Biol. 2017; 15, 363-374.
    PubMed
  • Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. Schusdziarra C., Blamowska M., Azem A, Hell K. Hum Mol Genet. 2013 Apr 1;22(7):1348-57.
    PubMed
  • Divergent molecular evolution of the mitochondrial sulfhydryl:cytochrome C oxidoreductase Erv in opisthokonts and parasitic protists. Eckers E, Petrungaro C, Gross D, Riemer J, Hell K, Deponte M. J Biol Chem. 2013 Jan 25;288(4):2676-88.
    PubMed
  • Biogenesis of the mitochondrial Hsp70 chaperone. Blamowska M, Neupert W, Hell K. J Cell Biol. 2012 Oct 1;199(1):125-35. doi: 10.1083/jcb.201205012. Epub 2012 Sep 24.
    PubMed

2011 - 2008

  • Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system. Groß DP, Burgard CA, Reddehase S, Leitch JM, Culotta VC, Hell K. Mol Biol Cell. 2011 Aug 24.
    PubMed
  • ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1. Blamowska M, Sichting M, Mapa K, Mokranjac D, Neupert W, Hell K. J Biol Chem. 2010 Feb 12;285(7):4423-31.
    PubMed
  • Deponte M, Hell K. Disulphide bond formation in the intermembrane space of mitochondria. J Biochem. 2009 Nov;146(5):599-608.
    PubMed
  • Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria. Mokranjac D, Sichting M, Popov-Celeketić D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W. Mol Biol Cell. 2009 Mar;20(5):1400-7.
    PubMed
  • Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex. Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic D, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D. J Biol Chem. 2009 Feb 20;284 (8):4865-72.
    PubMed
  • Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria. Terziyska N, Grumbt B, Kozany C, Hell K. J Biol Chem. 2009 Jan 16;284(3):1353-63.
    PubMed
  • The disulfide relay system of mitochondria is required for the biogenesis of mitochondrial Ccs1 and Sod1. Reddehase S, Grumbt B, Neupert W, Hell K. J Mol Biol. 2009 Jan 16;385(2):331-8.
    PubMed
  • The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40. Mesecke N, Bihlmaier K, Grumbt B, Longen S, Terziyska N, Hell K, Herrmann JM. EMBO Rep. 2008 Nov;9(11):1107-13.
    PubMed
  • The Erv1-Mia40 disulfide relay system in the intermembrane space of mitochondria. Hell K. Biochim Biophys Acta. 2008 Apr;1783(4):601-9.
    PubMed

2007 - 2004

  • The disulfide relay system of mitochondria is connected to the respiratory chain. Bihlmaier K, Mesecke N, Terziyska N, Bien M, Hell K, Herrmann JM. J Cell Biol. 2007 Nov 5;179(3):389-95.
    PubMed
  • Functional characterization of Mia40p, the central component of the disulfide relay system of the mitochondrial intermembrane space. Grumbt B, Stroobant V, Terziyska N, Israel L, Hell K. J Biol Chem. 2007 Dec 28;282(52):37461-70.
    PubMed
  • Association of the Tim14.Tim16 subcomplex with the TIM23 translocase is crucial for function of the mitochondrial protein import motor. Mokranjac D, Berg A, Adam A, Neupert W, Hell K. J Biol Chem. 2007 Jun 22;282(25):18037-45.
    PubMed
  • The sulfhydryl oxidase Erv1 is a substrate of the Mia40-dependent protein translocation pathway. Terziyska N, Grumbt B, Bien M, Neupert W, Herrmann JM, Hell K. FEBS Lett. 2007 Mar 20;581(6):1098-102.
    PubMed
  • Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. Mokranjac D, Bourenkov G, Hell K, Neupert W, Groll M. EMBO J. 2006 Oct 4;25(19):4675-85.
    PubMed
  • The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria. Adam AC, Bornhövd C, Prokisch H, Neupert W, Hell K. EMBO J. 2006 Jan 11;25(1):174-83.
    PubMed
  • Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space. Hofmann S, Rothbauer U, Mühlenbein N, Baiker K, Hell K, Bauer MF. J Mol Biol. 2005 Oct 28;353(3):517-28.
    PubMed
  • Influence of substrate binding on the mechanical stability of mouse dihydrofolate reductase. Junker JP, Hell K, Schlierf M, Neupert W, Rief M. Biophys J. 2005 Nov; 89 (5):L46-8.
    PubMed
  • The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2. Mokranjac D, Sichting M, Popov-Celeketić D, Berg A, Hell K, Neupert W. J Biol Chem. 2005 Sep 9;280(36):31608-14.
    PubMed
  • A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Mesecke N, Terziyska N, Kozany C, Baumann F, Neupert W, Hell K, Herrmann JM. Cell. 2005 Jul 1;121(7):1059-69.
    PubMed
  • Role of Tim21 in mitochondrial translocation contact sites. Mokranjac D, Popov-Celeketić D, Hell K, Neupert W. J Biol Chem. 2005 Jun 24;280(25):23437-40.
    PubMed
  • Chopped, trapped or tacked--protein translocation into the IMS of mitochondria. Herrmann JM, Hell K. Trends Biochem Sci. 2005 Apr;30(4):205-11.
    PubMed
  • Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1. Sichting M, Mokranjac D, Azem A, Neupert W, Hell K. EMBO J. 2005 Mar 9;24(5):1046-56.
    PubMed
  • Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions. Terziyska N, Lutz T, Kozany C, Mokranjac D, Mesecke N, Neupert W, Herrmann JM, Hell K. FEBS Lett. 2005 Jan 3;579(1):179-84.
    PubMed
  • Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. Waizenegger T, Habib SJ, Lech M, Mokranjac D, Paschen SA, Hell K, Neupert W, Rapaport D. EMBO Rep. 2004 Jul;5(7):704-9.
    PubMed
  • Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. Herlan M, Bornhövd C, Hell K, Neupert W, Reichert AS. J Cell Biol. 2004 Apr 26;165(2):167-73.
    PubMed
  • The J domain-related cochaperone Tim16 is a constituent of the mitochondrial TIM23 preprotein translocase. Kozany C, Mokranjac D, Sichting M, Neupert W, Hell K. Nat Struct Mol Biol. 2004 Mar;11(3):234-41.
    PubMed

 - 2003

  • Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Paschen SA, Waizenegger T, Stan T, Preuss M, Cyrklaff M, Hell K, Rapaport D, Neupert W. Nature. 2003 Dec 18;426(6968):862-6.
    PubMed
  • Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1. Jia L, Dienhart M, Schramp M, McCauley M, Hell K, Stuart RA. EMBO J. 2003 Dec 15;22(24):6438-47.
    PubMed
  • Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. Mokranjac D, Sichting M, Neupert W, Hell K. EMBO J. 2003 Oct 1; 22 (19):4945-56.
    PubMed
  • Tim50, a novel component of the TIM23 preprotein translocase of mitochondria. Mokranjac D, Paschen SA, Kozany C, Prokisch H, Hoppins SC, Nargang FE, Neupert W, Hell K. EMBO J. 2003 Feb 17;22(4):816-25.
    PubMed
  • Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae. Preuss M, Leonhard K, Hell K, Stuart RA, Neupert W, Herrmann JM. J Cell Biol. 2001 May 28;153(5).
    PubMed
  • Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA. Hell K, Neupert W, Stuart RA. EMBO J.2001 Mar15;20(6):1281-8.
    PubMed
  • Identification of Cox20p, a novel protein involved in the maturation and assembly of cytochrome oxidase subunit 2. Hell K, Tzagoloff A, Neupert W, Stuart RA.J Biol Chem. 2000 Feb 18;275(7):4571-8.
    PubMed
  • Bcs1p, an AAA-family member, is a chaperone for the assembly of the cytochrome bc(1) complex. Cruciat CM, Hell K, Fölsch H, Neupert W, Stuart RA. EMBO J. 1999 Oct 1;18(19):5226-33.
    PubMed
  • Oxa1p, an essential component of the N-tail protein export machinery in mitochondria. Hell K, Herrmann JM, Pratje E, Neupert W, Stuart RA. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2250-5.
    PubMed
  • Oxa1p mediates the export of the N- and C-termini of pCoxII from the mitochondrial matrix to the intermembrane space. Hell K, Herrmann J, Pratje E, Neupert W, Stuart RA. FEBS Lett. 1997 Dec 1;418(3):367-70.
    PubMed