Master thesis: Mitotic chromatin regulation by histone chaperones
Accurate chromosome segregation is essential for genome integrity and chromosome segregation errors are hallmarks of cancer. Accurate chromosome segregation requires orchestrated and spatial action of structural proteins, signaling pathways as well as dedicated centromeric chromatin factors.
Our team has recently identified novel functions in mitosis of two highly conserved histone chaperones in a model organism, fission yeast. The goal of this project is to establish molecular function(s) of those factors at centromeres and during chromosome segregation and to unveil mechanisms that drive their cell-cycle regulated chromatin recruitment.
The research groups of our department cover a broad range of topics and interdisciplinary methods. Within the department people are surrounded by international co-workers from different countries. Undergraduates, Masters, PhD students and Postdoc candidates interested in joining us, please contact the respective group leader or our Management Office.