Physiological Chemistry

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  1. A Poly-ADP-Ribose trigger releases the auto-inhibition of a chromatin remodeling oncogene.
    Singh HR, Nardozza AP, Möller IR, Knobloch G, Kistemaker HAV, Hassler M, Harrer N, Blessing C, Eustermann S, Kotthoff C, Huet S, Mueller-Planitz F, Filippov DV, Timinszky G, Rand KD and Ladurner AG.
    Mol Cell 2017; 68 (5), 860–871.
  2. The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
    Salas-Pino S, Gallardo P, Barrales RR, Braun S and Daga RR.
    J Cell Biol. 2017; 216(11), 3591-3608.
  3. MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.
    Marjanović MP, Hurtado-Bagès S, Lassi M, Valero V, Malinverni R, Delage H, Navarro M, Corujo D, Guberovic I, Douet J, Gama-Perez P, Garcia-Roves PM, Ahel I, Ladurner AG, Yanes O, Bouvet P, Suelves M, Teperino R, Pospisilik JA, Buschbeck M.
    Nat Struct Mol Biol. 2017; doi: 10.1038/nsmb.3481. [Epub ahead of print]
  4. Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50.
    Malhotra K, Modak A, Nangia S, Daman TH, Gunsel U, Robinson VL, Mokranjac D, May ER and Alder NN.
    Sci Adv. 2017; 3(9):e1700532.
  5. Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening.
    Arduino DM, Wettmarshausen J, Vais H, Navas-Navarro P, Cheng Y, Leimpek A, Ma Z, Delrio-Lorenzo A, Giordano A, Garcia-Perez C, Médard G, Kuster B, García-Sancho J, Mokranjac D, Foskett JK, Alonso MT and Perocchi F.
    Mol Cell. 2017; 67(4):711-723.
  6. The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.
    Flury V, Georgescu PR, Iesmantavicius V, Shimada Y, Kuzdere T, Braun S and Bühler M.
    Mol Cell. 2017; 67, 1–14.
  7. Remodelers tap into nucleosome plasticity.
    Singh HR, Murawska M and Ladurner AG.
    Nature Structural & Molecular Biology 2017; 24(4): 341-343.
  8. Chemical Crosslinking in Intact Mitochondria.
    Banerjee R, Günsel U and Mokranjac D.
    Methods Mol Biol. 2017; 1567:139-154.
  9. Role of Nhp6 and Hmo1 in SWI/SNF occupancy and nucleosome landscape at gene regulatory regions.
    Hepp MI, Smolle M, Gidi C, Amigo R, Valenzuela N, Arriagada A, Maureira A, Gogol MM, Torrejón M, Workman JL, and Gutiérrez JL.
    Biochim Biophys Acta. 2017; Mar;1860(3):316-326.
  10. Reversing ADP-ribosylation.
    Moeller GK and Timinszky G.
    Elife. 2017; 6. pii: e29942. doi: 10.7554/eLife.29942.
  11. Poly(ADP-Ribose)-Dependent Chromatin Remodeling in DNA Repair.
    Lebeaupin T, Smith R, Huet S and Timinszky G.
    Methods Mol Biol. 2017; 1608; 165-183.
  12. Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase.
    Demishtein-Zohary K, Günsel U, Marom M, Banerjee R, Neupert W, Azem A and Mokranjac D.
    Elife. 2017 Feb 6;6. pii:e22696. doi: 10.7554/eLife.22696
  13. sNASP and ASF1A function through both competitive and compatible modes of histone binding.
    Bowman A, Koide A, Goodman JS, Colling ME, Zinne D, Koide S and Ladurner AG.
    Nucleic Acids Res. 2017 Jan 25;45(2):643-656
  14. ATM induces MacroD2 nuclear export upon DNA damage.
    Golia B, Moeller GK, Jankevicius G, Schmidt A, Hegele A, Preißer J, Tran ML, Imhof A, Timinszky G.
    Nucleic Acids Res. 2017 Jan 9;45(1):244-254
  15. The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage.
    Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh HR, Kozlowski M, Bultmann S, Ladurner AG, Timinszky G and Huet S.
    Mol Biol Cell. 2016 Dec 1;27(24):3791-3799
  16. Nick Your DNA, Mark Your Chromatin.
    Nardozza AP and Ladurner AG.
    Mol Cell. 2016 Oct 6;64(1): 7-9.
  17. CENPs and Sweet Nucleosomes Face the FACT.
    Murawska M, Ladurner AG.
    Trends Biochem Sci. 2016 Aug 4. pii: S0968-0004(16)30097-4. doi: 10.1016/j.tibs.2016.07.010.
  18. Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides.
    Kistemaker HA, Nardozza AP, Overkleeft HS, van der Marel GA, Ladurner AG, Filippov DV.
    Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10634-10638.