Nucleosomes were first observed in the early 1970's, yet we still do not have a comprehensive understanding of how they are assembled and disassembled. When outside of chromatin, soon after their synthesis, or after their eviction from DNA, histones are found associated with a number of soluble proteins termed 'histone chaperones', and a number of histone modifying complexes, most notably the histone acetyl transferases (HATs). Recent evidence suggests there exists a number of chaperone-HAT networks that are involved in ferrying histones to and from DNA and in targeting old histones for destruction.
My research is focused on defining these interactions at the molecular level using a number of biochemical, structural and synthetic biology approaches. Specifically I am interested in deciphering the molecular mechanisms that control the passage of histones from one complex to another and how these affect cellular physiology.
University of Warwick
Coventry CV4 7AL