The parasite Trypanosoma brucei causes sleeping sickness. It evades human defences by changing the version of a protein that coats its surface.
In this paper the group of Nicolai Siegel report the de novo haplotype-specific assembly and scaffolding of the long antigen-gene arrays of the model protozoan parasite Trypanosoma brucei, using long-read sequencing technology and conserved features of chromosome folding. Genome-wide chromosome conformation capture reveals a distinct partitioning of the genome, with antigen-encoding subtelomeric regions that are folded into distinct, highly compact compartments.
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