Physiological Chemistry

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Andreas Ladurner and his team is one of the winners of the BioM m4 Award 2021. In their project "SugarSwitch" they are developing agonists or antagonists for a transcription factor that is crucially involved in sugar and lipid homeostasis. more

Proper regulation of RNA processing is critical for muscle development and the fine-tuning of contractile ability among muscle fiber-types. RNA binding proteins regulate the diverse steps in RNA processing, which generates fiber-type specific isoforms of structural proteins that confer contractile sarcomeres with distinct biomechanical properties. We use Drosophila as a powerful model to gain disease-relevant insight into cellular and molecular phenotypes observed when expression levels of splicing factors, spliceosome components and splicing dynamics are altered. more