Physiological Chemistry
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Publications

2017 -2015

  • Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50.
    Malhotra K, Modak A, Nangia S, Daman TH, Gunsel U, Robinson VL, Mokranjac D, May ER and Alder NN.
    Sci Adv. 2017; 3(9):e1700532.
    PubMed 
  • Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening.
    Arduino DM, Wettmarshausen J, Vais H, Navas-Navarro P, Cheng Y, Leimpek A, Ma Z, Delrio-Lorenzo A, Giordano A, Garcia-Perez C, Médard G, Kuster B, García-Sancho J, Mokranjac D, Foskett JK, Alonso MT and Perocchi F.
    Mol Cell. 2017; 67(4):711-723.
    PubMed 
  • Chemical Crosslinking in Intact Mitochondria.
    Banerjee R, Günsel U and Mokranjac D.
    Methods Mol Biol. 2017; 1567:139-154.
    PubMed 
  • Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase.
    Demishtein-Zohary K, Günsel U, Marom M, Banerjee R, Neupert W, Azem A and Mokranjac D.
    Elife. 2017 Feb 6;6. pii:e22696. doi: 10.7554/eLife.22696
    PubMed
  • Mitochondrial protein import: An unexpected disulfide bond.
    Mokranjac D.
    Cell Biol. 2016 Aug 15;214(4):363-5.
    PubMed
  • Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein.
    Banerjee R, Gladkova C, Mapa K, Witte G, and Mokranjac D.
    Elife. 2015 Dec 29;4. pii: e11897. doi: 10.7554/eLife.11897.
    PubMed
  • Cell biology: Architecture of a protein entry gate
    Mokranjac D and Neupert W.
    Nature. 2015 Dec 10;528(7581):201-2.
    PubMed
  • Nucleotides regulate the mechanical hierarchy between subdomains of the nucleotide binding domain of the Hsp70 chaperone DnaK.
    Bauer D, Merz DR, Pelz B, Theisen KE, Yacyshyn G, Mokranjac D, Dima RI, Rief M, and Žoldák G.
    Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10389-94.
    PubMed
  • GxxxG Motifs hold the TIM23 Complex Together.
    Demishtein-Zohary K, Marom M, Neupert W, Mokranjac D, Azem A.
    FEBS J. 2015 Mar 12. doi: 10.1111/febs.13266.
    PubMed
  • Editorial Overview: Elucidation of Protein Translocation Pathways, Part II.
    Mokranjac D, High S
    J Mol Biol. 2015 Mar 27;427(6 Pt A): 1133-4.
    PubMed
  • Functional Complementation Analyses Reveal that the Single PRAT-Family Protein of Trypanosoma brucei is a Divergent Homolog of Tim17 in Saccharomyces cerevisiae.
    Weems E, Singha UK, Hamilton V, Smith JT, Waegemann K, Mokranjac D, Chaudhuri M.
    Eukaryot Cell. 2015 Jan 9. pii: EC.00203-14.
    PubMed 

2014 - 2012

  • Cooperation of TOM and TIM23 Complexes during Translocation of Proteins into Mitochondria. Waegemann K, Popov-Čeleketić D, Neupert W, Azem A and Mokranjac D.
    J Mol Biol. 2014 Jul 30. DOI: 10.1016/j.jmb.2014.07.015
    PubMed
  • Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1. Burbulla LF, Fitzgerald JC, Stegen K, Westermeier J, Thost AK, Kato H, Mokranjac D, Sauerwald J, Martins LM, Woitalla D, Rapaport D, Riess O, Proikas-Cezanne T, Rasse TM, Krüger R.
    Cell Death Dis. 2014; 5(4): e1180.
    PubMed 
  • Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET. Sikor M, Mapa K, Voith von Voithenberg L, Mokranjac D and Don C Lamb.
    The EMBO Journal, 2013 (32), 1639 - 1649.
    PubMed
  • Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria. Schreiner B, Westerburg H, Forné I, Imhof A, Neupert W, Mokranjac D.
    Mol Biol Cell. 2012 Sep 19.
    PubMed
  • Combining MFD and PIE for accurate single-pair Förster resonance energy transfer measurements. Kudryavtsev V, Sikor M, Kalinin S, Mokranjac D, Seidel CA, Lamb DC. Chemphyschem. 2012 Mar;13(4):1060-78.
    PubMed 

2011 - 2008

  • The mitochondrial contact site complex, a determinant of mitochondrial architecture. Harner M, Körner C, Walther D, Mokranjac D, Kaesmacher J, Welsch U, Griffith J, Mann M, Reggiori F, Neupert W. EMBO J. 2011 Oct 18;30(21):4356-70
    PubMed
  • Direct interaction of mitochondrial targeting presequences with purified components of the TIM23 complex. Marom M, Dayan D, Demishtein-Zohary K, Mokranjac D, Neupert W, Azem A. J Biol Chem. 2001 Oct 3.
    PubMed
  • Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex. Popov-Čeleketić D, Waegemann K, Mapa K, Neupert W, Mokranjac D. EMBO Rep. 2011 Jun;12(6):542-8.
    PubMed
  • Understanding the molecular mechanism of protein translocation across the mitochondrial inner membrane: still a long way to go. Marom M, Azem A, Mokranjac D. Biochim Biophys Acta. 2011 Mar;1808(3):990-1001.
    PubMed
  • The many faces of the mitochondrial TIM23 complex. Mokranjac D, Neupert W. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1045-54.
    PubMed
  • The conformational dynamics of the mitochondrial Hsp70 chaperone. Mapa K, Sikor M, Kudryavtsev V, Waegemann K, Kalinin S, Seidel CA, Neupert W, Lamb DC, Mokranjac D. Mol Cell. 2010 Apr 9;38(1):89-100.
    PubMed
  • ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1. Blamowska M, Sichting M, Mapa K, Mokranjac D, Neupert W, Hell K. J Biol Chem. 2010 Feb 12;285(7):4423-31.
    PubMed
  • Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria. Mokranjac D, Sichting M, Popov-Celeketić D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W. Mol Biol Cell. 2009 Mar;20(5):1400-7.
    PubMed
  • Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex. Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic D, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D. J Biol Chem.2009 Feb 20;284(8): 4865-72.
    PubMed
  • Thirty years of protein translocation into mitochondria: unexpectedly complex and still puzzling. Mokranjac D, Neupert W. Biochim Biophys Acta. 2009 Jan; 1793(1):33-41.
    PubMed
  • Energetics of protein translocation into mitochondria. Mokranjac D, Neupert W. Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):758-62.
    PubMed
  • Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria. Popov-Celeketić D, Mapa K, Neupert W, Mokranjac D. EMBO J. 2008 May 21;27(10):1469-80.
    PubMed

2007 - 2004

  • Association of the Tim14.Tim16 subcomplex with the TIM23 translocase is crucial for function of the mitochondrial protein import motor. Mokranjac D, Berg A, Adam A, Neupert W, Hell K. J Biol Chem. 2007 Jun 22;282(25):18037-45.
    PubMed
  • Protein import into isolated mitochondria. Mokranjac D, Neupert W. Methods Mol Biol. 2007;372:277-86.
    PubMed
  • Characterization of the preprotein and amino acid transporter gene family in Arabidopsis. Murcha MW, Elhafez D, Lister R, Tonti-Filippini J, Baumgartner M, Philippar K, Carrie C, Mokranjac D, Soll J, Whelan J. Plant Physiol. 2007 Jan ; 143 (1):199-212.
    PubMed
  • Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. Mokranjac D, Bourenkov G, Hell K, Neupert W, Groll M. EMBO J. 2006 Oct 4;25(19):4675-85.
    PubMed
  • Protein import into mitochondria. Mokranjac D, Neupert W. Biochem Soc Trans. 2005 Nov;33(Pt 5):1019-23.
    PubMed
  • The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2. Mokranjac D, Sichting M, Popov-Celeketić D, Berg A, Hell K, Neupert W. J Biol Chem. 2005 Sep 9;280(36):31608-14.
    PubMed
  • Role of Tim21 in mitochondrial translocation contact sites. Mokranjac D, Popov-Celeketić D, Hell K, Neupert W. J Biol Chem. 2005 Jun 24;280(25):23437-40.
    PubMed
  • Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1. Sichting M, Mokranjac D, Azem A, Neupert W, Hell K. EMBO J. 2005 Mar 9;24(5):1046-56.
    PubMed
  • Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions. Terziyska N, Lutz T, Kozany C, Mokranjac D, Mesecke N, Neupert W, Herrmann JM, Hell K. FEBS Lett. 2005 Jan 3;579(1):179-84.
    PubMed
  • Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. Waizenegger T, Habib SJ, Lech M, Mokranjac D, Paschen SA, Hell K, Neupert W, Rapaport D. EMBO Rep. 2004 Jul;5(7):704-9.
    PubMed
  • The J domain-related cochaperone Tim16 is a constituent of the mitochondrial TIM23 preprotein translocase. Kozany C, Mokranjac D, Sichting M, Neupert W, Hell K. Nat Struct Mol Biol. 2004 Mar;11(3):234-41.
    PubMed

- 2003

  • Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. Mokranjac D, Sichting M, Neupert W, Hell K. EMBO J. 2003 Oct 1; 22(19):4945-56.
    PubMed
  • Tim50, a novel component of the TIM23 preprotein translocase of mitochondria. Mokranjac D, Paschen SA, Kozany C, Prokisch H, Hoppins SC, Nargang FE, Neupert W, Hell K. EMBO J. 2003 Feb 17;22(4):816-25.
    PubMed
  • Systematic screen for human disease genes in yeast. Steinmetz LM, Scharfe C, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW. Nat Genet. 2002 Aug;31(4):400-4.
    PubMed