Physiological Chemistry

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  • Reversing ADP-ribosylation.
    Moeller GK and Timinszky G.
    Elife. 2017; 6. pii: e29942. doi: 10.7554/eLife.29942.
  • Poly(ADP-Ribose)-Dependent Chromatin Remodeling in DNA Repair.
    Lebeaupin T, Smith R, Huet S and Timinszky G.
    Methods Mol Biol. 2017; 1608; 165-183.
  • ATM induces MacroD2 nuclear export upon DNA damage.
    Golia B, Moeller GK, Jankevicius G, Schmidt A, Hegele A, Preißer J, Tran ML, Imhof A, Timinszky G.
    Nucleic Acids Res. 2017 Jan 9;45(1):244-254
  • The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage.
    Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh HR, Kozlowski M, Bultmann S, Ladurner AG, Timinszky G and Huet S.
    Mol Biol Cell. 2016 Dec 1;27(24):3791-3799
  • Poly-ADP-ribosylation signaling during DNA damage repair.
    Golia B, Singh HR, and Timinszky G.
    Front Biosci (Landmark Ed) 2015, Jan 1;20: 440-57.
  • PARP1 and CBP lose their footing in cancer. Timinszky G and Ladurner AG.
    Nat Struct Mol Biol. 2014 Nov 5;21(11):947-948.
  • Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 provide insights into circadian function. Czarna A, Berndt A, Singh HR, Grudziecki A, Ladurner AG, Timinszky G, Kramer A and Wolf E.
    Cell, 2013 153(6), 1394–1405.
  • The recognition and removal of cellular poly(ADP-ribose) signals. Barkauskaite E, Jankevicius G, Ladurner AG, Ahel I, Timinszky G.
    FEBS J., 2013 280(15), 3491-507.
  • Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. Sharifi R, Morra R, Appel CD, Tallis M, Chioza B, Jankevicius G, Simpson MA, Matic I, Ozkan E, Golia B, Schellenberg MJ, Weston R, Williams JG, Rossi MN, Galehdari H, Krahn J, Wan A, Trembath RC, Crosby AH, Ahel D, Hay R, Ladurner AG, Timinszky G, Williams RS and Ahel I.
    The EMBO Journal 2013 March 12, doi:10.1038/emboj.2013.51
  • A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G and Ladurner AG.
    Nature Structural & Molecular Biology. 2013 March; doi:10.1038/nsmb.2523
  • Macro domains as metabolite sensors on chromatin. Posavec M, Timinszky G and Buschbeck M.
    Cell Mol Life Sci. 2013 March 3.
  • The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Ali AEA, Timinszky G, R Arribas-Bosacoma, Kozlowski M, Hassa PO, Hassler M, Ladurner AG, Pearl LH, and Oliver AW.
    Nature Structural & Molecular Biology. 2012 June 10; doi:10.1038/nsmb.2335
  • A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG.
    Nat Struct Mol Biol. 2009 Sep;16(9):923-9.
  • Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP, Florens L, Ladurner AG, Conaway JW, Conaway RC.
    Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13770-4.
  • Repression of RNA polymerase II transcription by a Drosophila oligopeptide. Timinszky G, Bortfeld M, Ladurner AG.
    PLoS One. 2008 Jun 25;3(6):e2506.
  • Long persistence of importin-beta explains extended survival of cells and zygotes that lack the encoding gene. Villányi Z, Debec A, Timinszky G, Tirián L, Szabad J.
    Mech Dev. 2008 Mar-Apr;125(3-4):196-206.
  • P446L-importin-beta inhibits nuclear envelope assembly by sequestering nuclear envelope assembly factors to the microtubules. Tirián L, Timinszky G, Szabad J.
    Eur J Cell Biol. 2003 Jul;82(7):351-9.
  • The importin-beta P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope. Timinszky G, Tirián L, Nagy FT, Tóth G, Perczel A, Kiss-László Z, Boros I, Clarke PR, Szabad J.
    J Cell Sci. 2002 Apr 15;115(Pt 8):1675-87.