Research News
19.11.2024
Maria Colomé-Tatché receives funding to study cancer focusing on copy number variations. Maria's team is advancing the understanding of cancer by focusing on a genetic phenomenon known as aneuploidy.
Congratulations to Maren Heimhalt (PhD), a Postdoctoral researcher in the group of Prof. Andreas Ladurner. Maren has been awarded a GO-BIO initial funding by the Federal Ministry of Education and Research (BMBF).
In a current collaborative Nature publication, the group of Nicolai Siegel explored the dynamics of antigenic variation in extravascular Trypanosoma brucei populations. By applying VSG-seq. they show that tissues, not the blood, are the primary reservoir of antigenic diversity during T. brucei infections. This increased diversity is correlated with slower parasite clearance in tissue spaces. Their findings reveal the important role that extravascular spaces can have in pathogen diversification.
In this recent publication in Cell Reports, the group of Andreas Ladurner demosntrate that the histone chaperone ANP32B is a regulator of macroH2A deposition. In a collaborative approach they developed a split-GFP-based assay for chromatin incorporation and used it to conduct a genome-wide mutagenesis screen in haploid human cells to identify proteins that regulate macroH2A dynamics.
In their recent publication in Nature Communications, the research group of Maria Colomé-Tatché describes the algorithm called epiAneufinder. It exploits the read count information from scATAC-seq data to extract genome-wide copy number alterations for individual cells.
Charlotte Blessing, former PhD student in the group of Prof. Andreas Ladurner, has been awarded the Dr. Hildegard and Heinrich Fuchs Prize for the promotion of young medical professionals in 2023 at the Medical Faculty.
