Physiological Chemistry
print

Links and Functions

Breadcrumb Navigation


Content

Publications

2018

  • MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.
    Kozlowski M, Corujo D, Hothorn M, Guberovic I, Mandemaker IK, Blessing C, Sporn J, Gutierrez-Triana A, Smith R, Portmann T, Treier M, Scheffzek K, Huet S, Timinszky G, Buschbeck M and Ladurner AG.
    EMBO Rep. 2018 e44445; DOI 10.15252/embr.201744445
    PubMed

2017 - 2015

  • A Poly-ADP-Ribose trigger releases the auto-inhibition of a chromatin remodeling oncogene.
    Singh HR, Nardozza AP, Möller IR, Knobloch G, Kistemaker HAV, Hassler M, Harrer N, Blessing C, Eustermann S, Kotthoff C, Huet S, Mueller-Planitz F, Filippov DV, Timinszky G, Rand KD and Ladurner AG.
    Mol Cell 2017; 68 (5), 860–871.
    PubMed
  • MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.
    Marjanović MP, Hurtado-Bagès S, Lassi M, Valero V, Malinverni R, Delage H, Navarro M, Corujo D, Guberovic I, Douet J, Gama-Perez P, Garcia-Roves PM, Ahel I, Ladurner AG, Yanes O, Bouvet P, Suelves M, Teperino R, Pospisilik JA, Buschbeck M.
    Nat Struct Mol Biol. 2017; doi: 10.1038/nsmb.3481. [Epub ahead of print]
    PubMed
  • Remodelers tap into nucleosome plasticity.
    Singh HR, Murawska M and Ladurner AG.
    Nature Structural & Molecular Biology 2017; 24(4): 341-343.
    PubMed
  • sNASP and ASF1A function through both competitive and compatible modes of histone binding.
    Bowman A, Koide A, Goodman JS, Colling ME, Zinne D, Koide S and Ladurner AG.
    Nucleic Acids Res. 2017 Jan 25;45(2):643-656
    PubMed
  • The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage.
    Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh HR, Kozlowski M, Bultmann S, Ladurner AG, Timinszky G and Huet S.
    Mol Biol Cell. 2016 Dec 1;27(24):3791-3799
    PubMed
  • Nick Your DNA, Mark Your Chromatin.
    Nardozza AP and Ladurner AG.
    Mol Cell. 2016 Oct 6;64(1): 7-9.
    PubMed
  • CENPs and Sweet Nucleosomes Face the FACT.
    Murawska M, Ladurner AG.
    Trends Biochem Sci. 2016 Aug 4. pii: S0968-0004(16)30097-4. doi: 10.1016/j.tibs.2016.07.010.
    PubMed
  • Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides.
    Kistemaker HA, Nardozza AP, Overkleeft HS, van der Marel GA, Ladurner AG, Filippov DV.
    Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10634-10638.
    PubMed
  • The Metabolic Impact on Histone Acetylation and Transcription in Ageing.
    Peleg S, Feller C, Ladurner AG, Imhof A.
    Trends Biochem Sci. 2016 Aug;41(8):700-11.
    PubMed
  • The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1.
    Dell'Orso S, Wang AH, Shih HY, Saso K, Berghella L, Gutierrez-Cruz G, Ladurner AG, O'Shea JJ, Sartorelli V, Zare H.
    Cell Rep. 2016 Feb 9;14(5):1156-68.
    PubMed
  • Life span extension by targeting a link between metabolism and histone acetylation in Drosophila.
    Peleg S, Feller C, Forne I, Schiller E, Sévin DC, Schauer T, Regnard C, Straub T, Prestel M, Klima C, Schmitt Nogueira M, Becker L, Klopstock T, Sauer U, Becker PB, Imhof A, and Ladurner AG.
    EMBO reports 2016 DOI 10.15252/embr.201541132. Published online 18.01.2016
    Article
  • The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats.
    Bowman A, Lercher L, Singh HR, Zinne D, Timinszky G, Carlomagno T, and Ladurner AG.
    Nucleic Acids Res. 2015 Dec 15. pii: gkv1372. [Epub ahead of print]
    PubMed
  • ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence.
    Kozlowski M, Ladurner AG.
    Mol Cell. 2015 Sep 3;59(5):713-5.
    PubMed
  • Designing Cell-Type-Specific Genome-wide Experiments.
    Handley A, Schauer T, Ladurner AG, and Margulies CE.
    Mol Cell. 2015 May 21;58(4): 621-631.
    PubMed

2014 - 2012

  • PARP1 and CBP lose their footing in cancer.
    Timinszky G
    and Ladurner AG.
    Nat Struct Mol Biol. 2014 Nov 5;21(11):947-948.
    PubMed
  • ACF Takes the Driver's Seat.
    Singh HR
    and Ladurner AG.
    Mol Cell. 2014 Aug 7;55(3), 345-6.
    PubMed
  • Catch me if you can: How the histone chaperone FACT capitalizes on nucleosome breathing.
    Hondele M
    and Ladurner AG.
    Nucleus 2013; Dec 5;4(6)
    PubMed
  • CAST-ChIP Maps Cell-Type-Specific Chromatin States in the Drosophila Central Nervous System.
    Schauer T, Schwalie PC, Handley A, Margulies CE, Flicek P and Ladurner AG.
    Cell Reports, 2013 Oct 17;5(1), 271-82.
    PubMed
  • Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 provide insights into circadian function. Czarna A, Berndt A, Singh HR, Grudziecki A, Ladurner AG, Timinszky G, Kramer A and Wolf E.
    Cell, 2013 153(6), 1394–1405.
    PubMed
  • The recognition and removal of cellular poly(ADP-ribose) signals. Barkauskaite E, Jankevicius G, Ladurner AG, Ahel I, Timinszky G.
    FEBS J., 2013 280(15), 3491-507.
    PubMed
  • Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Hondele M, Stuwe T, Hassler M, Halbach F, Bowman A, Zhang E, Nijmeijer B, Kotthoff C, Rybin V, Amlacher S, Hurt E and Ladurner AG.
    Nature, 2013 Jul 4; 499(7456):111-4.
    PubMed
  • Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. Sharifi R, Morra R, Appel CD, Tallis M, Chioza B, Jankevicius G, Simpson MA, Matic I, Ozkan E, Golia B, Schellenberg MJ, Weston R, Williams JG, Rossi MN, Galehdari H, Krahn J, Wan A, Trembath RC, Crosby AH, Ahel D, Hay R, Ladurner AG, Timinszky G, Williams RS and Ahel I.
    The EMBO Journal, 2013 (32).
    PubMed
  • A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G and Ladurner AG. Nature Structural & Molecular Biology. 2013 March; doi:10.1038/nsmb.2523
    PubMed
  • Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains. Forst AH, Karlberg T, Herzog N, Thorsell AG, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner AG, Schüler H, Lüscher B.
    Structure. 2013 Mar 5;21(3):462-75.
    PubMed 
  • Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
    PNAS 2013, Jan 22. [Epub ahead of print]
    PubMed
  • Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation. Oppikofer M, Kueng S, Keusch JJ, Hassler M, Ladurner AG, Gut H and Gasser SM.
    EMBO J. 2013, Jan 08.
    PubMed
  • Towards a structural understanding of PARP1 activation and related signaling ADP-ribosyltransferases. Hassler M. and Ladurner, AG.
    Current Opinion in Structural Biology 2012, doi: 10.1016/j.sbi.2012.08.005.

    PubMed
  • The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Ali AEA, Timinszky G, R Arribas-Bosacoma, Kozlowski M, Hassa PO, Hassler M, Ladurner AG, Pearl LH, and Oliver AW.
    Nature Structural & Molecular Biology. 2012 June 10; doi:10.1038/nsmb.2335
    Abstract
  • A unified phylogeny-based nomenclature for histone variants. Talbert PB, Ahmad K, Almouzni G, Ausió J, Berger F, Bhalla PL, Bonner WM, Cande WZ, Chadwick BP, Chan SW, Cross GA, Cui L, Dimitrov SI, Doenecke D, Eirin-López JM, Gorovsky MA, Hake SB, Hamkalo BA, Holec S, Jacobsen SE, Kamieniarz K, Khochbin S, Ladurner AG, Landsman D, Latham JA, Loppin B, Malik HS, Marzluff WF, Pehrson JR, Postberg J, Schneider R, Singh MB, Smith MM, Thompson E, Torres-Padilla ME, Tremethick DJ, Turner BM, Waterborg JH, Wollmann H, Yelagandula R, Zhu B, Henikoff S.
    Epigenetics Chromatin. 2012 May 31;5(1):7
    PubMed

2011 - 2008

  • The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticity. Hondele M, Ladurner AG. Curr Opin Struct Biol. 2011 Nov 2.
    PubMed
  • PARG: A Macrodomain in Disguise. Hassler M, Jankevicius G, Ladurner AG. Structure. 2011 Oct 12;19(10):1351-3.
    PubMed
  • Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79. Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE. Genes Dev. 2011 Sep 1;25(17):1835-46.
    PubMed
  • Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression. Murawska M, Hassler M, Renkawitz-Pohl R, Ladurner A, Brehm A. PLoS Genet. 2011 Jul;7(7):e1002206.
    PubMed
  • A mitotic beacon reveals its nucleosome anchor. Hondele M, Ladurner AG. Mol Cell. 2010 Sep 24;39(6):829-30.
    PubMed
  • SirT1 in muscle physiology and disease: lessons from mouse models. Vinciguerra M, Fulco M, Ladurner AG, Sartorelli V, Rosenthal N. Dis Model Mech. 2010 May-Jun;3(5-6):298-303.
    PubMed
  • A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG. Nat Struct Mol Biol. 2009 Sep;16(9):923-9.
    PubMed
  • Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP, Florens L, Ladurner AG, Conaway JW, Conaway RC. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13770-4.
    PubMed
  • Histone macroH2A isoforms predict the risk of lung cancer recurrence. Sporn JC, Kustatscher G, Hothorn M, Collado M, Serrano M, Muley T, Schnabel P, Ladurner AG. Oncogene. 2009 Sep 24;28(38):3423-8.
    PubMed
  • Chromatin places metabolism center stage. Ladurner AG. Cell. 2009 Jul 10;138(1):18-20.
    PubMed
  • Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A. Science. 2009 Apr 24;324(5926):513-6.
    PubMed
  • Sensing NAD metabolites through macro domains. Till S, Ladurner AG. Front Biosci. 2009 Jan 1;14:3246-58.
    PubMed
  • Combining affinity purification by ADP-ribose-binding macro domains with mass spectrometry to define the mammalian ADP-ribosyl proteome. Dani N, Stilla A, Marchegiani A, Tamburro A, Till S, Ladurner AG, Corda D, Di Girolamo M. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4243-8.
    PubMed
  • Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Vinciguerra M, Santini MP, Claycomb WC, Ladurner AG, Rosenthal N. Aging (Albany NY). 2009 Dec 10;2(1):43-62.
    PubMed
  • N terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex. Wu WH, Wu CH, Ladurner AG, Mizuguchi G, Wei D, Xiao H, Luk E, Ranjan A, Wu C. J Biol Chem. 2009 Mar 6; 284(10):6200-7.
    PubMed
  • PARP: a transferase by any other name. Till S, Diamantara K, Ladurner AG. Nat Struct Mol Biol. 2008 Dec;15(12):1243-4.
    PubMed
  • The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module. Stuwe T, Hothorn M, Lejeune E, Rybin V, Bortfeld M, Scheffzek K, Ladurner AG. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8884-9.
    PubMed
  • Repression of RNA polymerase II transcription by a Drosophila oligopeptide. Timinszky G, Bortfeld M, Ladurner AG. PLoS One. 2008 Jun 25;3(6):e2506.
    PubMed
  • A metabolic throttle regulates the epigenetic state of rDNA. Grummt I, Ladurner AG. Cell 2008 May 16;133(4):577-80.
    PubMed

2007 – 2004

  • RNA Pol IV plays catch with Argonaute 4. Till S, Ladurner AG. Cell. 2007 Nov 16 ; 131 (4):643-5.
  • An acetylation switch in p53 mediates holo-TFIID recruitment. Li AG, Piluso LG, Cai X, Gadd BJ, Ladurner AG, Liu X. Mol Cell. 2007 Nov 9;28(3):408-21.
  • Modular paths to 'decoding' and 'wiping' histone lysine methylation. Kustatscher G, Ladurner AG. Curr Opin Chem Biol. 2007 Dec;11(6):628-35.
  • A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain. Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG. Nat Struct Mol Biol. 2007 Oct;14(10):897-903.
  • Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. Alonso A, Fritz B, Hasson D, Abrusan G, Cheung F, Yoda K, Radlwimmer B, Ladurner AG, Warburton PE. Genome Biol. 2007;8 (7):R148.
  • The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi. Lejeune E, Bortfeld M, White SA, Pidoux AL, Ekwall K, Allshire RC, Ladurner AG. Curr Biol. 2007 Jul 17;17(14):1219-24.
  • Rheostat control of gene expression by metabolites. Ladurner AG. Mol Cell. 2006 Oct 6;24(1):1-11.
  • Splicing regulates NAD metabolite binding to histone macroH2A. Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG. Nat Struct Mol Biol. 2005 Jul;12 (7): 624-5.
  • The macro domain is an ADP-ribose binding module. Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG. EMBO J. 2005 Jun 1;24(11):1911-20.
  • Hitting transcription in all the right places. Lejeune E, Ladurner AG. Nat Struct Mol Biol. 2005 May;12(5):390-2.

 - 2003

  • Inactivating chromosomes: a macro domain that minimizes transcription. Ladurner AG. Mol Cell. 2003 Jul;12(1):1-3.
  • Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries. Ladurner AG, Inouye C, Jain R, Tjian R. Mol Cell. 2003 Feb;11(2):365-76.
  • Tick-tock goes the acetylation clock. Ladurner AG. Nat Struct Biol. 2003 Feb;10(2):83.
  • Mutations of penicillin acylase residue B71 extend substrate specificity by decreasing steric constraints for substrate binding. Morillas M, McVey CE, Brannigan JA, Ladurner AG, Forney LJ, Virden R. Biochem J. 2003 Apr 1;371(Pt 1):143-50.
  • From an armadillo to electricity. Ladurner AG. Nat Struct Biol. 2003 Jan;10(1):12.
  • Picture story. Sabotage through structural mimicry. Ladurner AG. Nat Struct Biol. 2002 Dec;9(12):899.
  • The origin of silence. Ladurner AG. Nat Struct Biol. 2002 Oct;9(10):718.
  • Structure and function of a human TAFII250 double bromodomain module. Jacobson RH, Ladurner AG, King DS, Tjian R. Science. 2000 May 26;288(5470):1422-5.
  • Three-dimensional structure of the human TFIID-IIA-IIB complex. Andel F 3rd, Ladurner AG, Inouye C, Tjian R, Nogales E. Science. 1999 Dec 10;286(5447):2153-6.
  • The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Ryu S, Zhou S, Ladurner AG, Tjian R. Nature. 1999 Feb 4;397 (6718):446-50.
  • Upper limit of the time scale for diffusion and chain collapse in chymotrypsin inhibitor 2. Ladurner AG, Fersht AR. Nat Struct Biol. 1999 Jan;6(1):28-31.
  • Synergy between simulation and experiment in describing the energy landscape of protein folding. Ladurner AG, Itzhaki LS, Daggett V, Fersht AR.Proc Natl Acad Sci USA. 1998 Jul 21;95(15):8473-8.
  • Glutamine, alanine or glycine repeats inserted into the loop of a protein have minimal effects on stability and folding rates. Ladurner AG, Fersht AR. J Mol Biol. 1997 Oct 17;273(1):330-7.
  • Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2. Ladurner AG, Itzhaki LS, de Prat Gay G, Fersht AR. J Mol Biol. 1997 Oct17; 273(1):317-29.
  • Following co-operative formation of secondary and tertiary structure in a single protein module. Neira JL, Itzhaki LS, Ladurner AG, Davis B, de Prat Gay G, Fersht AR. J Mol Biol. 1997 Apr 25;268(1):185-97.
  • Strain in the folding nucleus of chymotrypsin inhibitor 2. Ladurner AG, Itzhaki LS, Fersht AR. Fold Des. 1997;2(6):363-8.
  • Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism. Neira JL, Davis B, Ladurner AG, Buckle AM, Gay Gde P, Fersht AR. Fold Des. 1996;1(3):189-208.
  • Conformational pathway of the polypeptide chain of chymotrypsin inhibitor-2 growing from its N terminus in vitro. Parallels with the protein folding pathway. de Prat Gay G, Ruiz-Sanz J, Neira JL, Corrales FJ, Otzen DE, Ladurner AG, Fersht AR. J Mol Biol. 1995 Dec 15;254(5):968-79.