Physiological Chemistry

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2011 - 2008

  1. The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticity. Hondele M, Ladurner AG. Curr Opin Struct Biol. 2011 Nov 2.
  2. Direct interaction of mitochondrial targeting presequences with purified components of the TIM23 complex. Marom M, Dayan D, Demishtein-Zohary K, Mokranjac D, Neupert W, Azem A. J Biol Chem. 2011 Oct 3.
  3. The mitochondrial contact site complex, a determinant of mitochondrial architecture. Harner M, Körner C, Walther D, Mokranjac D, Kaesmacher J, Welsch U, Griffith J, Mann M, Reggiori F, Neupert W. EMBO J. 2011 Oct 18;30(21):4356-70
  4. PARG: A Macrodomain in Disguise. Hassler M, Jankevicius G, Ladurner AG. Structure. 2011 Oct 12;19(10):1351-3.
  5. Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system. Groß DP, Burgard CA, Reddehase S, Leitch JM, Culotta VC, Hell K. Mol Biol Cell. 2011 Mol Biol Cell. 2011 Oct;22(20):3758-3767.
  6. Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79. Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE. Genes Dev. 2011 Sep 1;25(17):1835-46.
  7. Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression. Murawska M, Hassler M, Renkawitz-Pohl R, Ladurner A, Brehm A. PLoS Genet. 2011 Jul;7(7):e1002206.
  8. Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex. Popov-Čeleketić D, Waegemann K, Mapa K, Neupert W, Mokranjac D. EMBO Rep. 2011 Jun;12(6):542-8
  9. Understanding the molecular mechanism of protein translocation across the mitochondrial inner membrane: still a long way to go. Marom M, Azem A, Mokranjac D. Biochim Biophys Acta. 2011 Mar;1808(3):990-1001.
  10. A mitotic beacon reveals its nucleosome anchor. Hondele M, Ladurner AG. Mol Cell. 2010 Sep 24;39(6):829-30.
  11. SirT1 in muscle physiology and disease: lessons from mouse models. Vinciguerra M, Fulco M, Ladurner AG, Sartorelli V, Rosenthal N. Dis Model Mech. 2010 May-Jun;3(5-6):298-303.
  12. The many faces of the mitochondrial TIM23 complex. Mokranjac D, Neupert W. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1045-54.
  13. The conformational dynamics of the mitochondrial Hsp70 chaperone. Mapa K, Sikor M, Kudryavtsev V, Waegemann K, Kalinin S, Seidel CA, Neupert W, Lamb DC, Mokranjac D. Mol Cell. 2010 Apr 9;38(1):89-100.
  14. ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1. Blamowska M, Sichting M, Mapa K, Mokranjac D, Neupert W, Hell K. J Biol Chem. 2010 Feb 12;285(7):4423-31.
  15. Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Vinciguerra M, Santini MP, Claycomb WC, Ladurner AG, Rosenthal N. Aging (Albany NY). 2009 Dec 10;2(1):43-62.
  16. A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG. Nat Struct Mol Biol. 2009 Sep;16(9):923-9.
  17. Histone macroH2A isoforms predict the risk of lung cancer recurrence. Sporn JC, Kustatscher G, Hothorn T, Collado M, Serrano M, Muley T, Schnabel P, Ladurner AG. Oncogene. 2009 Sep 24;28(38):3423-8.
  18. Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP, Florens L, Ladurner AG, Conaway JW, Conaway RC. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13770-4.
  19. Chromatin places metabolism center stage. Ladurner AG. Cell. 2009 Jul 10;138 (1):18-20.
  20. Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A. Science. 2009 Apr 24;324(5926):513-6.
  21. Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria. Mokranjac D, Sichting M, Popov-Celeketić D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W. Mol Biol Cell. 2009 Mar;20(5):1400-7.
  22. Combining affinity purification by ADP-ribose-binding macro domains with mass spectrometry to define the mammalian ADP-ribosyl proteome. Dani N, Stilla A, Marchegiani A, Tamburro A, Till S, Ladurner AG, Corda D, Di Girolamo M. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4243-8.
  23. N terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex. Wu WH, Wu CH, Ladurner AG, Mizuguchi G, Wei D, Xiao H, Luk E, Ranjan A, Wu C. J Biol Chem. 2009 Mar 6; 284(10):6200-7.
  24. Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex. Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic D, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D. J Biol Chem. 2009 Feb 20;284 (8):4865-72.
  25. Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria. Terziyska N, Grumbt B, Kozany C, Hell K. J Biol Chem. 2009 Jan 16;284(3):1353-63.
  26. The disulfide relay system of mitochondria is required for the biogenesis of mitochondrial Ccs1 and Sod1. Reddehase S, Grumbt B, Neupert W, Hell K. J Mol Biol. 2009 Jan 16;385(2):331-8.
  27. Sensing NAD metabolites through macro domains. Till S, Ladurner AG. Front Biosci. 2009 Jan 1;14:3246-58.
  28. Thirty years of protein translocation into mitochondria: unexpectedly complex and still puzzling. Mokranjac D, Neupert W. Biochim Biophys Acta. 2009 Jan;1793(1):33.
  29. PARP: a transferase by any other name. Till S, Diamantara K, Ladurner AG. Nat Struct Mol Biol. 2008 Dec;15(12):1243-4
  30. The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40. Mesecke N, Bihlmaier K, Grumbt B, Longen S, Terziyska N, Hell K, Herrmann JM. EMBO Rep. 2008 Nov;9(11):1107-13.
  31. The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module. Stuwe T, Hothorn M, Lejeune E, Rybin V, Bortfeld M, Scheffzek K, Ladurner AG. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8884-9.
  32. Energetics of protein translocation into mitochondria. Mokranjac D, Neupert W. Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):758-62.
  33. Repression of RNA polymerase II transcription by a Drosophila oligopeptide. Timinszky G, Bortfeld M, Ladurner AG. PLoS One. 2008 Jun 25;3(6):e2506.
  34. A metabolic throttle regulates the epigenetic state of rDNA. Grummt I, Ladurner AG. Cell. 2008 May 16;133(4):577-80.
  35. Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria. Popov-Celeketić D, Mapa K, Neupert W, Mokranjac D. EMBO J. 2008 May 21;27(10):1469-80.
  36. The Erv1-Mia40 disulfide relay system in the intermembrane space of mitochondria. Hell K. Biochim Biophys Acta. 2008 Apr;1783(4):601-9.
  37. Long persistence of importin-beta explains extended survival of cells and zygotes that lack the encoding gene. Villányi Z, Debec A, Timinszky G, Tirián L, Szabad J. Mech Dev. 2008 Mar-Apr;125(3-4):196-206.