Physiological Chemistry

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  1. Allele-specific assembly of a eukaryotic genome corrects apparent frameshifts and reveals a lack of nonsense-mediated mRNA decay.
    Cosentino RO, Brink BG and Siegel TN.
    NAR Genom Bioinform. 2021 Sep 16;3(3):lqab082. doi: 10.1093/nargab/lqab082. eCollection 2021
  2. The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.
    Murawska M, Greenstein RA, Schauer T, Olsen KCF, Ng H, Ladurner AG, Al-Sady B and Braun S.
    Cell Rep. 2021, DOI:
  3. Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1.
    Liu Q, Knobloch G, Voorneveld J, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Ladurner AG and Filippov DV.
    Chem Sci. 2021 Aug 18;12(37):12468-12475. doi: 10.1039/d1sc02340c. eCollection 2021 Sep 29.
  4. A Candidate RNAi Screen Reveals Diverse RNA-Binding Protein Phenotypes in Drosophila Flight Muscle.
    Kao S-Y*, Nikonova E*, Chaabane S, Sabani A, Martitz A, Wittner A, Heemken J, Straub T and Spletter ML.
    Cells 2021, 10(10), 2505;
  5. EpiScanpy: integrated single-cell epigenomic analysis
    Danese A, Richter ML, Chaichoompu K, Fischer DS, Theis FJ and Colomé-Tatché M.
    Nat Commun. 2021 Sep 1;12(1):5228. doi: 10.1038/s41467-021-25131-3.
  6. Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation.
    Valera-Alberni M, Joffraud M, Miro-Blanch J, Capellades J, Junza A, Dayon L, Galindo AN, Sanchez-Garcia JL, Valsesia A, Cercillieux A, Söllner F, Ladurner AG, Yanes O and Cantó C.
    Cell Rep. 2021 Aug 24;36(8):109565. doi: 10.1016/j.celrep.2021.109565.
  7. Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.
    Capella M, Mandemaker IK, Caballero Martín L, den Brave F, Pfander B, Ladurner AG, Jentsch S. and Braun S.
    Nat Commun. 2021 Aug 13;12(1):4918. doi: 10.1038/s41467-021-25205-2.
  8. Cell-to-Cell Heterogeneity in Trypanosomes.
    Luzak V, López-Escobar L, Siegel TN and Figueiredo LM.
    Annu Rev Microbiol. 2021, Jul 6. doi: 10.1146/annurev-micro-040821-012953. Online ahead of print.
  9. Crosstalk between H2A variant-specific modifications impacts vital cell functions.
    Schmücker A, Lei B, Lorković ZJ, Capella M, Braun S, Bourguet P, Mathieu O, Mechtler K and Berger F.
    PLoS Genet. 2021, Jun 4;17(6):e1009601. doi: 10.1371/journal.pgen.1009601. eCollection 2021 Jun.
  10. Rbfox1 is required for myofibril development and maintaining fiber-type specific isoform expression in Drosophila muscles.
    Nikonova E, Kamble K, Mukherjee A, Barz C, Nongthomba U and Spletter ML.
    bioRxiv 2021, doi:
  11. A triskelion of nucleic acids drives protein aggregation in A-T.
    Gonzalez-Leal C and Ladurner AG.
    Mol Cell 2021, Apr 01;81(7):1367-1369.
  12. Features of MOG required for recognition by patients with MOG antibody-associated disorders.
    Macrini C, Gerhards R, Winklmeier S, Bergmann L, Mader S, Spadaro M, Vural A, Smolle M, Hohlfeld R, Kümpfel T, Lichtenthaler SF, Franquelim HG, Jenne D, Meinl E.
    Brain. 2021 Mar 11:awab105. doi: 10.1093/brain/awab105. Online ahead of print.
  13. Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes.
    Faria J, Luzak V, Müller L.S.M., Brink BG, Hutchinson S, Glover L, Horn D and Siegel TN.
    Nature Microbiology 2021;