Physiological Chemistry

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before 2003

  • Nucleosome positioning signals in the DNA sequence of the human and mouse H19 imprinting control regions. Davey C, Fraser R, Smolle M, Simmen MW and Allan J.
    J Mol Biol. 2003 Jan 31;325(5):873-87.
  • Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Paschen SA, Waizenegger T, Stan T, Preuss M, Cyrklaff M, Hell K, Rapaport D, Neupert W. Nature. 2003 Dec 18;426(6968):862-6.
  • Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1. Jia L, Dienhart M, Schramp M, McCauley M, Hell K, Stuart RA. EMBO J. 2003 Dec 15;22(24):6438-47.
  • Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. Mokranjac D, Sichting M, Neupert W, Hell K. EMBO J. 2003 Oct 1; 22 (19):4945-56.
  • Inactivating chromosomes: a macro domain that minimizes transcription. Ladurner AG. Mol Cell. 2003 Jul;12(1):1-3.
  • P446L-importin-beta inhibits nuclear envelope assembly by sequestering nuclear envelope assembly factors to the microtubules. Tirián L, Timinszky G, Szabad J. Eur J Cell Biol. 2003 Jul;82(7):351-9.
  • Mutations of penicillin acylase residue B71 extend substrate specificity by decreasing steric constraints for substrate binding. Morillas M, McVey CE, Brannigan JA, Ladurner AG, Forney LJ, Virden R. Biochem J. 2003 Apr 1;371(Pt 1):143-50.
  • Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries. Ladurner AG, Inouye C, Jain R, Tjian R. Mol Cell. 2003 Feb;11(2):365-76.
  • Tick-tock goes the acetylation clock. Ladurner AG. Nat Struct Biol. 2003 Feb;10(2):83.
  • Tim50, a novel component of the TIM23 preprotein translocase of mitochondria. Mokranjac D, Paschen SA, Kozany C, Prokisch H, Hoppins SC, Nargang FE, Neupert W, Hell K. EMBO J. 2003 Feb 17;22(4):816-25.
  • From an armadillo to electricity. Ladurner AG. Nat Struct Biol. 2003 Jan;10(1):12.
  • Picture story. Sabotage through structural mimicry. Ladurner AG. Nat Struct Biol. 2002 Dec;9(12):899.
  • The origin of silence. Ladurner AG. Nat Struct Biol. 2002 Oct;9(10):718.
  • Systematic screen for human disease genes in yeast. Steinmetz LM, Scharfe C, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW. Nat Genet. 2002 Aug;31(4):400-4.
  • The importin-beta P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope. Timinszky G, Tirián L, Nagy FT, Tóth G, Perczel A, Kiss-László Z, Boros I, Clarke PR, Szabad J. J Cell Sci. 2002 Apr 15;115(Pt 8):1675-87.
  • Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae. Preuss M, Leonhard K, Hell K, Stuart RA, Neupert W, Herrmann JM. J Cell Biol. 2001 May 28;153(5).
  • Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA. Hell K, Neupert W, Stuart RA. EMBO J.2001 Mar15;20(6):1281-8.
  • dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein. Keller SA, Mao Y, Struffi P, Margulies C, Yurk CE, Anderson AR, Amey RL, Moore S, Ebels JM, Foley K, Corado M, Arnosti DN. Mol Cell Biol. 2000 Oct;20(19): 7247-58.
  • Structure and function of a human TAFII250 double bromodomain module. Jacobson RH, Ladurner AG, King DS, Tjian R. Science. 2000 May 26;288(5470):1422-5.
  • Identification of Cox20p, a novel protein involved in the maturation and assembly of cytochrome oxidase subunit 2. Hell K, Tzagoloff A, Neupert W, Stuart RA.J Biol Chem. 2000 Feb 18;275(7):4571-8.
  • Three-dimensional structure of the human TFIID-IIA-IIB complex. Andel F 3rd, Ladurner AG, Inouye C, Tjian R, Nogales E. Science. 1999 Dec 10;286(5447):2153-6.
  • Bcs1p, an AAA-family member, is a chaperone for the assembly of the cytochrome bc(1) complex. Cruciat CM, Hell K, Fölsch H, Neupert W, Stuart RA. EMBO J. 1999 Oct 1;18(19):5226-33.
  • Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradient. Hewitt GF, Strunk BS, Margulies C, Priputin T, Wang XD, Amey R, Pabst BA, Kosman D, Reinitz J, Arnosti DN. Development. 1999 Mar;126(6):1201-10.
  • The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Ryu S, Zhou S, Ladurner AG, Tjian R. Nature. 1999 Feb 4;397 (6718):446-50.
  • Upper limit of the time scale for diffusion and chain collapse in chymotrypsin inhibitor 2. Ladurner AG, Fersht AR. Nat Struct Biol. 1999 Jan;6(1):28-31.
  • The FIS protein fails to block the binding of DnaA protein to oriC, the Escherichia coli chromosomal origin. Margulies C, Kaguni JM. Nucleic Acids Res. 1998 Nov 15 ; 26 (22):5170-5.
  • Synergy between simulation and experiment in describing the energy landscape of protein folding. Ladurner AG, Itzhaki LS, Daggett V, Fersht AR.Proc Natl Acad Sci USA. 1998 Jul 21;95(15):8473-8.
  • Oxa1p, an essential component of the N-tail protein export machinery in mitochondria. Hell K, Herrmann JM, Pratje E, Neupert W, Stuart RA. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2250-5.
  • Glutamine, alanine or glycine repeats inserted into the loop of a protein have minimal effects on stability and folding rates. Ladurner AG, Fersht AR. J Mol Biol. 1997 Oct 17;273(1):330-7.
  • Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2. Ladurner AG, Itzhaki LS, de Prat Gay G, Fersht AR. J Mol Biol. 1997 Oct17; 273(1):317-29.
  • Following co-operative formation of secondary and tertiary structure in a single protein module. Neira JL, Itzhaki LS, Ladurner AG, Davis B, de Prat Gay G, Fersht AR. J Mol Biol. 1997 Apr 25;268(1):185-97.
  • Strain in the folding nucleus of chymotrypsin inhibitor 2. Ladurner AG, Itzhaki LS, Fersht AR. Fold Des. 1997;2(6):363-8.
  • Oxa1p mediates the export of the N- and C-termini of pCoxII from the mitochondrial matrix to the intermembrane space. Hell K, Herrmann J, Pratje E, Neupert W, Stuart RA. FEBS Lett. 1997 Dec 1;418(3):367-70.
  • Domains of DnaA protein involved in interaction with DnaB protein, and in unwinding the Escherichia coli chromosomal origin. Marszalek J, Zhang W, Hupp TR, Margulies C, Carr KM, Cherry S, Kaguni JM. J Biol Chem. 1996 Aug 2;271(31):18535.
  • Ordered and sequential binding of DnaA protein to oriC, the chromosomal origin of Escherichia coli. Margulies C, Kaguni JM. J Biol Chem. 1996 Jul 19;271(29):17035-40.
  • Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism. Neira JL, Davis B, Ladurner AG, Buckle AM, Gay Gde P, Fersht AR. Fold Des. 1996;1(3):189-208.
  • Conformational pathway of the polypeptide chain of chymotrypsin inhibitor-2 growing from its N terminus in vitro. Parallels with the protein folding pathway. de Prat Gay G, Ruiz-Sanz J, Neira JL, Corrales FJ, Otzen DE, Ladurner AG, Fersht AR. J Mol Biol. 1995 Dec 15;254(5):968-79.